Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | EED | O75530 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 9/20 | 0.39 |
| ▸ | HTR2A | P28223 | 9/20 | 0.39 |
| ▸ | DRD3 | P35462 | 8/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.33 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599216 | 1.00 | SLC6A4 (0.42) | SLC6A4SLC6A2SLC6A3HTR1AEED | |
| SCHEMBL6599220 | 1.00 | SLC6A4 (0.42) | SLC6A4SLC6A2SLC6A3HTR1AEED | |
| SCHEMBL9934194 | 0.80 | HTR2C (0.47) | SLC6A4SLC6A2SLC6A3HTR1AEED | |
| Methylamine SCHEMBL27481194 | 0.77 | SLC6A4 (0.49) | SLC6A4SLC6A2SLC6A3HTR1AEED | |
| Sulfuric Acid SCHEMBL7955030 | 0.75 | DRD2 (0.43) | SLC6A4DRD2HTR2ADRD3 | |
| Sulfuric Acid SCHEMBL7955031 | 0.75 | DRD2 (0.43) | SLC6A4DRD2HTR2ADRD3 | |
| Sulfuric Acid SCHEMBL7955029 | 0.75 | DRD2 (0.43) | SLC6A4DRD2HTR2ADRD3 | |
| SCHEMBL8485551 | 0.73 | SLC6A4 (0.49) | SLC6A4SLC6A2SLC6A3HTR1AEED | |
| SCHEMBL6330817 | 0.72 | HTR2C (0.53) | PLGHTR2CHTR2B | |
| SCHEMBL6330813 | 0.72 | HTR2C (0.53) | PLGHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204660-B1 | SEROTONERGIC BENZOTHIOPHENES | LILLY CO ELI (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-1204660-A1 | SEROTONERGIC BENZOTHIOPHENES | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001009126-A1 | SEROTONERGIC BENZOTHIOPHENES | ELI LILLY AND COMPANY (US) | 2001-02-08 | — | — | WO | disclosed |