Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 4/20 | 1.00 |
| ▸ | CCR2 | P41597 | 16/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7083775 | 0.88 | ABCB11 (0.78) | ABCB11CCR2ALDH1A1GAAMAPT | |
| SCHEMBL6599266 | 0.87 | ABCB11 (0.77) | ABCB11CCR2ALDH1A1GAAMAPT | |
| SCHEMBL6598122 | 0.85 | ABCB11 (0.74) | ABCB11CCR2ALDH1A1GAAMAPT | |
| SCHEMBL6599182 | 0.85 | ABCB11 (0.73) | ABCB11CCR2 | |
| SCHEMBL6781272 | 0.83 | ABCB11 (0.71) | ABCB11CCR2 | |
| SCHEMBL21465476 | 0.81 | ABCB11 (0.68) | ABCB11CCR2ALDH1A1MAPTPKM | |
| SCHEMBL21465479 | 0.80 | ABCB11 (0.67) | ABCB11CCR2ALDH1A1MAPTPKM | |
| SCHEMBL6780182 | 0.80 | ABCB11 (0.66) | ABCB11CCR2 | |
| SCHEMBL5213205 | 0.79 | ABCB11 (0.66) | ABCB11CCR2ALDH1A1MAPTPKM | |
| SCHEMBL5212313 | 0.77 | ABCB11 (0.62) | ABCB11CCR2ALDH1A1MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150952-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-10-27 | — | — | EP | disclosed |
| US-6737435-B1 | ANTIINFLAMMATORY AGENTS; MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) DISEASES | ASTRAZENECA AB (SE) | 2004-05-18 | — | — | US | disclosed |