Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 2/20 | 0.66 |
| ▸ | CCR2 | P41597 | 9/20 | 0.62 |
| ▸ | EDNRB | P24530 | 3/20 | 0.50 |
| ▸ | EDNRA | P25101 | 2/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RGS12 | O14924 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5212313 | 0.90 | ABCB11 (0.62) | ABCB11CCR2EDNRBEDNRAPLA2G2A | |
| SCHEMBL5216231 | 0.89 | ABCB11 (0.52) | ABCB11CCR2PLA2G2AMEN1RGS12 | |
| SCHEMBL5214261 | 0.81 | ABCB11 (0.51) | ABCB11CCR2PLA2G2AMEN1RGS12 | |
| SCHEMBL6599243 | 0.79 | ABCB11 (1.00) | ABCB11CCR2ALDH1A1MAPTPKM | |
| SCHEMBL6302418 | 0.76 | ABCB11 (0.55) | ABCB11CCR2EDNRBEDNRAPLA2G2A | |
| SCHEMBL6302422 | 0.76 | ABCB11 (0.55) | ABCB11CCR2EDNRBEDNRAPLA2G2A | |
| SCHEMBL7076664 | 0.75 | ABCB11 (0.53) | ABCB11CCR2EDNRBEDNRAPLA2G2A | |
| SCHEMBL7076665 | 0.75 | ABCB11 (0.53) | ABCB11CCR2EDNRBEDNRAPLA2G2A | |
| SCHEMBL21465478 | 0.73 | CCR2 (0.64) | ABCB11CCR2MEN1ALDH1A1LMNA | |
| SCHEMBL21465499 | 0.73 | ABCB11 (0.58) | ABCB11CCR2MEN1RGS12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173421-B1 | INDOLE DERIVATIVES AS ANTI-INFLAMMATION AGENTS | ASTRAZENECA AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| US-6833387-B1 | 3-substituted indoles; inhibition of monocyte chemoattractant protein-1 and/or RANTES induced chemotaxis; inflammatory diseases | ASTRAZENECA AB (SE) | 2004-12-21 | — | — | US | disclosed |
| EP-1173421-A2 | INDOLE DERIVATIVES AS ANTI-INFLAMMATION AGENTS | AstraZeneca AB (SE) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000046199-A2 | INDOLE DERIVATIVES AS ANTI-INFLAMMATION AGENTS | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |