Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599282 | 1.00 | NPSR1 (0.43) | NPSR1LMNAHPGDALDH1A1MAPT | |
| SCHEMBL6601785 | 0.89 | NPSR1 (0.41) | NPSR1LMNAHPGDALDH1A1MAPT | |
| SCHEMBL6601782 | 0.89 | NPSR1 (0.41) | NPSR1LMNAHPGDALDH1A1MAPT | |
| SCHEMBL6600003 | 0.85 | NPSR1 (0.45) | NPSR1LMNAHPGDALDH1A1MAPT | |
| SCHEMBL6600004 | 0.85 | NPSR1 (0.45) | NPSR1LMNAHPGDALDH1A1MAPT | |
| SCHEMBL6600282 | 0.82 | KDM1A (0.42) | LMNAHPGDALDH1A1MAPTDAO | |
| SCHEMBL6600278 | 0.82 | KDM1A (0.42) | LMNAHPGDALDH1A1MAPTDAO | |
| SCHEMBL3186266 | 0.81 | VNN1 (0.39) | NPSR1LMNAL3MBTL1DAOKMT2A | |
| SCHEMBL3186276 | 0.81 | VNN1 (0.39) | NPSR1LMNAL3MBTL1DAOKMT2A | |
| SCHEMBL6600125 | 0.80 | MAPK1 (0.38) | NPSR1DAOKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756498-B2 | REARRANGEMENT OF AZIRINE COMPOUND OR PROTECTED DERIVATIVE THEREOF IN PRESENCE OF TRANSITION METAL CATALYST AND SOLVENT TO PRODUCE PYRAZOLOPYRIDINE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2004-06-29 | — | — | US | disclosed |
| EP-1276742-B1 | PROCESS FOR THE PREPARATION OF PYRAZOLOPYRIDINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2004-06-09 | — | — | EP | disclosed |
| US-20030212275-A1 | PROCESS FOR THE PREPARATION OF CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2003-11-13 | — | — | US | disclosed |
| EP-1276742-A2 | PROCESS FOR THE PREPARATION OF PYRAZOLOPYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-01-22 | — | — | EP | disclosed |
| WO-2001083479-A2 | PROCESS FOR THE PREPARATION OF PYRAZOLOPYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2001-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212275-A1 | PROCESS FOR THE PREPARATION OF CHEMICAL COMPOUNDS | CBR1, C1R, CBR3 | NPSR1 407/4885LMNA 2322/4885HPGD 2787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.