Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6600278 | 1.00 | KDM1A (0.42) | KDM1AMAOAMAOBRAB9AMRGPRX4 | |
| SCHEMBL3186276 | 0.87 | VNN1 (0.39) | KDM1AMAOAMAOBRAB9AKMT2A | |
| SCHEMBL3186266 | 0.87 | VNN1 (0.39) | KDM1AMAOAMAOBRAB9AKMT2A | |
| SCHEMBL6600122 | 0.85 | MAPK1 (0.38) | KDM1AMAOAMAOBMRGPRX4KMT2A | |
| SCHEMBL6600125 | 0.85 | MAPK1 (0.38) | KDM1AMAOAMAOBMRGPRX4KMT2A | |
| SCHEMBL6601782 | 0.84 | NPSR1 (0.41) | RAB9AMRGPRX4NPC1GLAHPGD | |
| SCHEMBL3441832 | 0.84 | CTSL (0.42) | MRGPRX4KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL3441829 | 0.84 | CTSL (0.42) | MRGPRX4KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL6601785 | 0.84 | NPSR1 (0.41) | RAB9AMRGPRX4NPC1GLAHPGD | |
| SCHEMBL6599285 | 0.82 | NPSR1 (0.43) | KMT2AGLAHPGDALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756498-B2 | REARRANGEMENT OF AZIRINE COMPOUND OR PROTECTED DERIVATIVE THEREOF IN PRESENCE OF TRANSITION METAL CATALYST AND SOLVENT TO PRODUCE PYRAZOLOPYRIDINE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2004-06-29 | — | — | US | disclosed |
| EP-1276742-B1 | PROCESS FOR THE PREPARATION OF PYRAZOLOPYRIDINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2004-06-09 | — | — | EP | disclosed |
| US-20030212275-A1 | PROCESS FOR THE PREPARATION OF CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2003-11-13 | — | — | US | disclosed |
| EP-1276742-A2 | PROCESS FOR THE PREPARATION OF PYRAZOLOPYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-01-22 | — | — | EP | disclosed |
| WO-2001083479-A2 | PROCESS FOR THE PREPARATION OF PYRAZOLOPYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2001-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212275-A1 | PROCESS FOR THE PREPARATION OF CHEMICAL COMPOUNDS | CBR1, C1R, CBR3 | KDM1A 581/4885MAOA 791/4885MAOB 508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.