Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.53 |
| ▸ | NOS1 | P29475 | 4/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | METAP2 | P50579 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | NEK2 | P51955 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 5/20 | 0.50 |
| ▸ | CLK1 | P49759 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6600480 | 0.85 | NOS1 (0.53) | NOS1MAPTMETAP2KDM4EMEN1 | |
| SCHEMBL29569257 | 0.81 | NOS1 (0.53) | ROCK2NOS1ROCK1MAPTMETAP2 | |
| SCHEMBL3722635 | 0.81 | NOS1 (0.53) | ROCK2NOS1ROCK1MAPTMETAP2 | |
| SCHEMBL182465 | 0.81 | NOS1 (0.53) | ROCK2NOS1ROCK1MAPTMETAP2 | |
| SCHEMBL12833351 | 0.81 | NOS1 (0.53) | ROCK2NOS1ROCK1MAPTMETAP2 | |
| SCHEMBL2659198 | 0.80 | MAOB (0.57) | ROCK2NOS1ROCK1MAPTMETAP2 | |
| SCHEMBL2659196 | 0.80 | MAOB (0.57) | ROCK2NOS1ROCK1MAPTMETAP2 | |
| SCHEMBL1754870 | 0.79 | NEK2 (0.62) | ROCK2NOS1ROCK1MAPTMETAP2 | |
| SCHEMBL20821115 | 0.78 | NOS1 (0.50) | ROCK2NOS1ROCK1MAPTMETAP2 | |
| SCHEMBL27904839 | 0.78 | NEK2 (0.47) | ROCK2NOS1ROCK1MAPTMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385833-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | Amgen Inc. (US) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002083654-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AMGEN INC. (US) | 2002-10-24 | — | — | WO | disclosed |