Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.53 |
| ▸ | METAP2 | P50579 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | NEK2 | P51955 | 1/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CLK1 | P49759 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29569257 | 1.00 | NOS1 (0.53) | NOS1ROCK2MAPTROCK1METAP2 | |
| SCHEMBL10658 | 0.86 | GSK3B (0.65) | NOS1ROCK2MAPTROCK1METAP2 | |
| SCHEMBL29569662 | 0.85 | NOS1 (0.53) | NOS1MAPTMETAP2KDM4EMEN1 | |
| SCHEMBL578417 | 0.85 | NOS1 (0.53) | NOS1MAPTMETAP2KDM4EMEN1 | |
| SCHEMBL12633807 | 0.82 | NOS1 (0.44) | NOS1ROCK2MAPTROCK1METAP2 | |
| SCHEMBL3722635 | 0.81 | NOS1 (0.53) | NOS1ROCK2MAPTROCK1METAP2 | |
| SCHEMBL12833351 | 0.81 | NOS1 (0.53) | NOS1ROCK2MAPTROCK1METAP2 | |
| SCHEMBL6599321 | 0.81 | ROCK2 (0.53) | NOS1ROCK2MAPTROCK1METAP2 | |
| SCHEMBL1754870 | 0.79 | NEK2 (0.62) | NOS1ROCK2MAPTROCK1METAP2 | |
| SCHEMBL20821115 | 0.78 | NOS1 (0.50) | NOS1ROCK2MAPTROCK1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 425 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11970456-B1 | Synthesis of thiosemicarbazide analogue as inhibitor of tyrosinase, skin hyperpigmentation, and fruit and/or vegetable browning | KING SAUD UNIVERSITY (SA) | 2024-04-30 | — | — | US | claimed |
| CN-114105879-B | Preparation of novel isophorone derivatives and application thereof in the fields of organelle labeling and viscosity detection | 苏州大学 | 2023-08-11 | — | — | CN | claimed |
| WO-2023087503-A1 | PREPARATION OF NOVEL ISOPHORONE DERIVATIVES AND USE THEREOF IN FIELDS OF ORGANELLE LABELING AND VISCOSITY DETECTION | 苏州大学 | 2023-05-25 | — | — | WO | claimed |
| CN-114105879-A | Preparation of novel isophorone derivative and application of novel isophorone derivative in fields of organelle marking and viscosity detection | 苏州大学 | 2022-03-01 | — | — | CN | claimed |
| CN-112266378-B | Imidazole derivative containing indazole structure and preparation method and application thereof | 延边大学 | 2021-10-12 | — | — | CN | claimed |
| CN-112266378-A | Imidazole derivative containing indazole structure and preparation method and application thereof | 延边大学 | 2021-01-26 | — | — | CN | claimed |
| CN-108884096-A | Spiral shell dihydroindolone as DDR1 inhibitor | 豪夫迈·罗氏有限公司 | 2018-11-23 | — | — | CN | claimed |
| US-20260109670-A1 | METHOD FOR ARYL DEBROMINATION AND ACYLATION OF BROMINATED BENZO-FUSED NITROGEN HETEROCYCLE | Shanghai OuChem Bio-Technology Co., LTD (CN) | 2026-04-23 | — | — | US | disclosed |
| US-12600717-B2 | Tricyclic compounds as inhibitors of KRAS | INCYTE CORPORATION (US) | 2026-04-14 | — | — | US | disclosed |
| US-20250340542-A1 | THYROID HORMONE RECEPTOR AGONISTS | INVENTISBIO CO LTD (CN) | 2025-11-06 | — | — | US | disclosed |
| US-20250340539-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1, AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2025-11-06 | — | — | US | disclosed |
| US-12391677-B2 | Thyroid hormone receptor agonists | InventisBio Co., Ltd. (CN) | 2025-08-19 | — | — | US | disclosed |
| US-20250215012-A1 | IKZF2 DEGRADERS AND USES THEREOF | UNIV MICHIGAN (US) | 2025-07-03 | — | — | US | disclosed |
| US-20040138286-A1 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2004-07-15 | — | — | US | disclosed |
| CN-1512987-A | Novel 1H-indazole compound | ������������ʽ���� | 2004-07-14 | — | — | CN | disclosed |
| US-20040063735-A1 | Calcitonin gene related peptide receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY | 2004-04-01 | — | — | US | disclosed |
| EP-1403255-A1 | Rho KINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-31 | — | — | EP | disclosed |
| WO-2003104236-A1 | CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-12-18 | — | — | WO | disclosed |
| US-6200978-B1 | FOR PREVENTING OR TREATING INFLAMMATORY DISEASES SUCH AS ARTHRITIS, PSORIASIS, ASTHMA, OR INFLAMMATORY BOWEL DISEASE, DISORDERS OF RESPIRATORY FUNCTION, GASTROINTESTINAL DISORDERS SUCH AS FUNCTIONAL BOWEL DISEASE, AS ANALGESICS | PFIZER INC. | 2001-03-13 | — | — | US | disclosed |
| CN-1176597-A | Benzothiopyranoindazoles antitumor agents | SANOFI WINTHROP INC (US) | 1998-03-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12600717-B2 | Tricyclic compounds as inhibitors of KRAS | KRAS, NRAS, HRAS | NOS1 4680/4885ROCK2 825/4885MAPT 4851/4885 |
| US-20040063735-A1 | Calcitonin gene related peptide receptor antagonists | CALCRL, CALCA, CALCR | NOS1 235/4885ROCK2 2945/4885MAPT 2563/4885 |
| US-12391677-B2 | Thyroid hormone receptor agonists | TSHR, THRA, TRHR | NOS1 2291/4885ROCK2 3086/4885MAPT 3701/4885 |
| US-20250215012-A1 | IKZF2 DEGRADERS AND USES THEREOF | IKZF1, IKZF2, IKZF3 | NOS1 4286/4885ROCK2 2911/4885MAPT 3386/4885 |
| US-20250340542-A1 | THYROID HORMONE RECEPTOR AGONISTS | TSHR, THRA, TRHR | NOS1 2214/4885ROCK2 3153/4885MAPT 3506/4885 |
| US-20260109670-A1 | METHOD FOR ARYL DEBROMINATION AND ACYLATION OF BROMINATED BENZO-FUSED NITROGEN HETEROCYCLE | NAT1, AADAC, NAA15 | NOS1 496/4885ROCK2 3631/4885MAPT 4076/4885 |
| US-20040138286-A1 | Rho kinase inhibitors | ROCK1, ROCK2, ARHGDIA | NOS1 131/4885ROCK2 2/4885MAPT 3261/4885 |
| US-11970456-B1 | Synthesis of thiosemicarbazide analogue as inhibitor of tyrosinase, skin hyperpigmentation, and fruit and/or vegetable browning | TYR, TH, PRKACA | NOS1 288/4885ROCK2 1419/4885MAPT 1559/4885 |
| US-20250340539-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1, AND/OR CLK4 | CLK1, CLK2, CLK3 | NOS1 2741/4885ROCK2 1040/4885MAPT 312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.