Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 10/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599602 | 0.91 | OPRD1 (0.54) | OPRD1OPRK1OPRM1HSD17B10ALDH1A1 | |
| SCHEMBL6174013 | 0.90 | OPRD1 (0.50) | OPRD1OPRK1OPRM1HSD17B10ALDH1A1 | |
| SCHEMBL6597970 | 0.84 | OPRD1 (0.52) | OPRD1OPRK1OPRM1CYP3A4CYP1A2 | |
| SCHEMBL6598590 | 0.83 | OPRD1 (0.64) | OPRD1OPRK1OPRM1 | |
| SCHEMBL6600455 | 0.82 | OPRD1 (0.48) | OPRD1OPRK1OPRM1ALDH1A1TSHR | |
| SCHEMBL6171193 | 0.82 | OPRD1 (0.52) | OPRD1OPRK1OPRM1ALDH1A1CYP3A4 | |
| SCHEMBL7667107 | 0.81 | OPRD1 (0.51) | OPRD1OPRK1OPRM1HSD17B10ALDH1A1 | |
| SCHEMBL6599265 | 0.81 | OPRD1 (0.59) | OPRD1OPRK1OPRM1ALDH1A1CYP3A4 | |
| SCHEMBL6600893 | 0.81 | OPRD1 (0.63) | OPRD1OPRK1OPRM1 | |
| SCHEMBL6598733 | 0.80 | OPRD1 (0.54) | OPRD1OPRK1OPRM1HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140835-B1 | 3,3-BIARYLPIPERIDINE AND 2,2-BIARYLMORPHOLINE DERIVATIVES | PFIZER PROD INC (US) | 2004-05-12 | — | — | EP | disclosed |
| US-20040063940-A1 | 3,3-Biarylpiperidine and 2,2-biarylmorpholine derivatives | PFIZER INC | 2004-04-01 | — | — | US | disclosed |
| US-6503905-B1 | Treating nervous system and gastrointestinal disorders; analgesics, antiasthmatics | PFIZER INC | 2003-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063940-A1 | 3,3-Biarylpiperidine and 2,2-biarylmorpholine derivatives | BCHE, HTR3C, CHRM2 | OPRD1 24/4885OPRK1 39/4885OPRM1 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.