Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TGM2 | P21980 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.44 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 3/20 | 0.43 |
| ▸ | PLK1 | P53350 | 3/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4987427 | 0.90 | ALDH1A1 (0.49) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL4987422 | 0.90 | ALDH1A1 (0.49) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL4990328 | 0.87 | FLT1 (0.50) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL4990335 | 0.87 | FLT1 (0.50) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL4992126 | 0.86 | ALDH1A1 (0.50) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL4992130 | 0.86 | ALDH1A1 (0.50) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL4993224 | 0.85 | ALDH1A1 (0.49) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL4993230 | 0.85 | ALDH1A1 (0.49) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL6608680 | 0.83 | ALDH1A1 (0.47) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL6608678 | 0.83 | ALDH1A1 (0.47) | ALDH1A1MAPTNPSR1KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430048-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | Allergan, Inc. (US) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003027102-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2003-04-03 | — | — | WO | disclosed |