Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TGM2 | P21980 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | PLK4 | O00444 | 2/20 | 0.40 |
| ▸ | PLK1 | P53350 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6608678 | 1.00 | ALDH1A1 (0.47) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL4992130 | 0.96 | ALDH1A1 (0.50) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL4992126 | 0.96 | ALDH1A1 (0.50) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL4999469 | 0.94 | ALDH1A1 (0.52) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL4999470 | 0.94 | ALDH1A1 (0.52) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL6599666 | 0.83 | ALDH1A1 (0.47) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL4991346 | 0.83 | KDR (0.50) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL4991358 | 0.83 | KDR (0.50) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL3572318 | 0.82 | GSK3B (0.42) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL3572316 | 0.82 | GSK3B (0.42) | ALDH1A1MAPTNPSR1KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430048-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | Allergan, Inc. (US) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003027102-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2003-04-03 | — | — | WO | disclosed |