Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CDC25C | P30307 | 4/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | BMP1 | P13497 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5383934 | 0.88 | MEN1 (0.47) | MEN1KMT2ATHRBAPEX1RECQL | |
| SCHEMBL6598928 | 0.85 | CALM1 (0.44) | MEN1KMT2ATDP1 | |
| SCHEMBL20380500 | 0.77 | CRHBP (0.59) | MEN1KMT2ACDC25CKCNH2ALDH1A1 | |
| SCHEMBL5383983 | 0.77 | CDC25C (0.60) | MEN1KMT2ACDC25CKCNH2MAPT | |
| SCHEMBL15267163 | 0.75 | SLC2A1 (0.56) | MEN1KMT2AKCNH2MAPTALDH1A1 | |
| SCHEMBL6983272 | 0.74 | QRFPR (0.44) | MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL6983275 | 0.74 | QRFPR (0.44) | MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL15264866 | 0.73 | SLC2A1 (0.56) | MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL15264861 | 0.73 | SLC2A1 (0.56) | MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL5384679 | 0.73 | CALM1 (0.42) | MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265891-B1 | NOVEL LIPOIC ACID HETEROCYCLIC OR BENZENE DERIVATIVES, PREPARATION AND USE THEREOF AS MEDICINES | CONSEILS DE RECH SET D APPLIC (FR) | 2004-12-29 | — | — | EP | disclosed |
| CN-1173969-C | Novel lipoic acid derivatives, their prepn., and pharmaceutical compositions containing them | ��ѧ�о���Ӧ����ѯ��˾ | 2004-11-03 | — | — | CN | disclosed |
| EP-1169316-B9 | NOVEL LIPOIC ACID DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SOD CONSEILS RECH APPLIC (FR) | 2003-10-29 | — | — | EP | disclosed |
| US-6605637-B1 | Nitrogen monoxide synthase inhibitors; such as n-(4-(((2-thienyl)(imino)methyl)amino)phenyl)-1,2-dithiolane-3-pentamide | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2003-08-12 | — | — | US | disclosed |
| EP-1169316-B1 | NOVEL LIPOIC ACID DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SOD CONSEILS RECH APPLIC (FR) | 2003-03-05 | — | — | EP | disclosed |
| CN-1349523-A | Novel lipoic acid derivatives, their prepn., and pharmaceutical compositions containing them | CONSEIL DE RECH S ET D APPLIC (FR) | 2002-05-15 | — | — | CN | disclosed |
| EP-1169316-A1 | NOVEL LIPOIC ACID DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000059899-A1 | NOVEL LIPOIC ACID DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SOCIETE DE CONSEIL DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2000-10-12 | — | — | WO | disclosed |