Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6808551 | 0.79 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL15571062 | 0.77 | ALDH1A1 (0.43) | CYP3A4KDM4EMAPTTGFBR1 | |
| SCHEMBL10992179 | 0.77 | MAPK14 (0.83) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| Hydrochloric Acid SCHEMBL30023185 | 0.76 | MAPK14 (0.80) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL11967202 | 0.75 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL6599716 | 0.75 | SNCA (0.46) | MAPK14MAPK13MAPK12MAPK11CYP3A4 | |
| Pyrimidine SCHEMBL6804171 | 0.72 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4536537 | 0.71 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4434902 | 0.70 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL6423292 | 0.70 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349851-A4 | COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-09-08 | — | — | EP | disclosed |
| EP-1349851-A1 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002040468-A1 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-05-23 | — | — | WO | disclosed |