Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | ACVR1B | P36896 | 3/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603473 | 0.87 | TGFBR1 (0.58) | RAB9AKDM4ENPC1SMN1; SMN2MAPT | |
| SCHEMBL6600949 | 0.82 | RAB9A (0.54) | RAB9AKDM4ENPC1SMN1; SMN2MAPT | |
| SCHEMBL6598082 | 0.81 | ADORA2A (0.44) | RAB9AKDM4ENPC1SMN1; SMN2MAPT | |
| SCHEMBL6601316 | 0.80 | TGFBR1 (0.50) | RAB9AKDM4ENPC1SMN1; SMN2MAPT | |
| SCHEMBL30139863 | 0.77 | TGFBR1 (0.64) | RAB9AKDM4ENPC1SMN1; SMN2MAPT | |
| SCHEMBL5930906 | 0.76 | SNCA (0.46) | SNCARAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL15188295 | 0.75 | TGFBR1 (0.57) | RAB9AKDM4ENPC1SMN1; SMN2MAPT | |
| SCHEMBL30203691 | 0.75 | SNCA (0.70) | SNCARAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL6600529 | 0.75 | MAPK14 (0.54) | KDM4EMAPTTGFBR1MAPK14MAPK13 | |
| SCHEMBL30139850 | 0.74 | TGFBR1 (0.54) | RAB9AKDM4ENPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349851-A4 | COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-09-08 | — | — | EP | disclosed |
| US-20040039198-A1 | Compounds | SMITHKLINE BEECHAM CORPORATION | 2004-02-26 | — | — | US | disclosed |
| EP-1349851-A1 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002040468-A1 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040039198-A1 | Compounds | SMAD3, SMAD2, TGFBR1 | SNCA 4760/4885RAB9A 4645/4885KDM4E 625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.