SCHEMBL6600745

SCHEMBL6600745

COc1ccc(C2=NN(C(=O)c3ccc(NC(C)=O)cc3)CCC2)cc1OC(F)(F)F

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.48
ALDH1A1 P00352 3/20 0.48
POLB P06746 1/20 0.48
PGR P06401 12/20 0.45
GAA P10253 1/20 0.44
PDE4B Q07343 1/20 0.41
CYP1A2 P05177 2/20 0.41
CYP2C9 P11712 2/20 0.41
CYP2C19 P33261 2/20 0.41
MAPT P10636 2/20 0.41
LMNA P02545 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
CYP3A4 P08684 1/20 0.41
HPGD P15428 1/20 0.41
MAPK10 P53779 1/20 0.41
WNT3A P56704 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6605449 0.93 ALDH1A1 (0.48) MAOBALDH1A1POLBPGRGAA
SCHEMBL6601921 0.92 MAOB (0.57) MAOBALDH1A1POLBPGRGAA
SCHEMBL146831 0.89 ALDH1A1 (0.44) MAOBALDH1A1POLBPGRGAA
SCHEMBL6605509 0.89 ABL1 (0.50) MAOBALDH1A1POLBLMNASMN1; SMN2
SCHEMBL7645940 0.88 ALDH1A1 (0.46) MAOBALDH1A1POLBPGRGAA
SCHEMBL6602525 0.87 ALDH1A1 (0.51) MAOBALDH1A1POLBPGRGAA
SCHEMBL6602107 0.87 NPC1 (0.48) ALDH1A1POLBPGRCYP1A2CYP2C9
SCHEMBL7647347 0.87 ALDH1A1 (0.42) MAOBALDH1A1POLBPGRGAA
SCHEMBL6604612 0.86 MAOB (0.49) MAOBALDH1A1POLBPGRGAA
SCHEMBL6604786 0.86 TSHR (0.47) ALDH1A1POLBCYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0922036-B1 ARYLALKANOYL PYRIDAZINES MERCK PATENT GMBH (DE) 2004-03-24 EP disclosed
US-6479494-B1 THEY INHIBIT SELECTIVELY PHOSPHODIESTERASE IV, WHICH CAUSES AN INCREASE OF THE INTRACELLULAR CAMP LEVEL AS CAMP INHIBITS BONE DECREASING CELLS AND STIMULATES BONE INCREASING CELLS FOR TREATMENT OF OSTEOPOROSIS MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 2002-11-12 US disclosed
US-6107295-A Arylalkanoyl pyridazines MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2000-08-22 US disclosed
EP-0922036-A1 ARYLALKANOYL PYRIDAZINES MERCK PATENT GmbH (DE) 1999-06-16 EP disclosed
WO-1998006704-A1 ARYLALKANOYL PYRIDAZINES MERCK PATENT GMBH (DE) 1998-02-19 WO disclosed