Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 5/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603307 | 0.92 | LMNA (0.54) | LMNAMAPK1HTTSMN1; SMN2L3MBTL1 | |
| Hydrochloric Acid SCHEMBL7652840 | 0.92 | LMNA (0.53) | LMNAMAPK1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL143145 | 0.91 | ABL1 (0.51) | ABL1LMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7645940 | 0.89 | ALDH1A1 (0.46) | ABL1ALDH1A1POLBCFTRMAOB | |
| SCHEMBL6600745 | 0.89 | MAOB (0.48) | LMNASMN1; SMN2ALDH1A1POLBMAOB | |
| SCHEMBL6605449 | 0.89 | ALDH1A1 (0.48) | ABL1LMNASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL6600453 | 0.88 | NPC1 (0.47) | ABL1LMNASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL6602107 | 0.88 | NPC1 (0.48) | ABL1LMNASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL7647347 | 0.88 | ALDH1A1 (0.42) | ABL1MAPK1ALDH1A1KMT2AMEN1 | |
| SCHEMBL6601230 | 0.88 | HTT (0.47) | LMNAMAPK1HTTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922036-B1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 2004-03-24 | — | — | EP | disclosed |
| US-6479494-B1 | THEY INHIBIT SELECTIVELY PHOSPHODIESTERASE IV, WHICH CAUSES AN INCREASE OF THE INTRACELLULAR CAMP LEVEL AS CAMP INHIBITS BONE DECREASING CELLS AND STIMULATES BONE INCREASING CELLS FOR TREATMENT OF OSTEOPOROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-11-12 | — | — | US | disclosed |
| US-6107295-A | Arylalkanoyl pyridazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-22 | — | — | US | disclosed |
| EP-0922036-A1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GmbH (DE) | 1999-06-16 | — | — | EP | disclosed |
| WO-1998006704-A1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |