Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602470 | 0.95 | PDE4B (0.44) | PDE4BSMN1; SMN2TSHRLMNAABCB1 | |
| SCHEMBL6602147 | 0.93 | PDE5A (0.46) | PDE4BSMN1; SMN2TSHRABCB1ABCG2 | |
| SCHEMBL6601945 | 0.92 | ABCG2 (0.53) | PDE4BSMN1; SMN2LMNAABCB1ABCG2 | |
| Hydrochloric Acid SCHEMBL7650717 | 0.91 | ABCG2 (0.53) | PDE4BSMN1; SMN2LMNAABCB1ABCG2 | |
| SCHEMBL6603434 | 0.88 | LMNA (0.50) | PDE4BSMN1; SMN2TSHRLMNAABCB1 | |
| Hydrochloric Acid SCHEMBL147488 | 0.87 | LMNA (0.49) | PDE4BSMN1; SMN2TSHRLMNAABCB1 | |
| SCHEMBL6602631 | 0.87 | ABCG2 (0.48) | PDE4BSMN1; SMN2LMNAABCB1ABCG2 | |
| SCHEMBL6606959 | 0.86 | ABCG2 (0.47) | PDE4BSMN1; SMN2LMNAABCB1ABCG2 | |
| SCHEMBL6601874 | 0.85 | ABCG2 (0.47) | PDE4BSMN1; SMN2ABCB1ABCG2MAPT | |
| SCHEMBL6600298 | 0.85 | AAK1 (0.50) | PDE4BSMN1; SMN2TSHRABCB1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922036-B1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 2004-03-24 | — | — | EP | disclosed |
| US-6479494-B1 | THEY INHIBIT SELECTIVELY PHOSPHODIESTERASE IV, WHICH CAUSES AN INCREASE OF THE INTRACELLULAR CAMP LEVEL AS CAMP INHIBITS BONE DECREASING CELLS AND STIMULATES BONE INCREASING CELLS FOR TREATMENT OF OSTEOPOROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-11-12 | — | — | US | disclosed |
| US-6107295-A | Arylalkanoyl pyridazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-22 | — | — | US | disclosed |