Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.46 |
| ▸ | UGCG | Q16739 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL5673576 | 0.93 | UGCG (0.43) | HRH3UGCGHDAC3HDAC4HDAC1 | |
| SCHEMBL6601516 | 0.87 | HRH3 (0.48) | HRH3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5675103 | 0.83 | CHRNA7 (0.41) | HRH3HTR3AALDH1A1MAPTNPC1 | |
| Bromide SCHEMBL5675094 | 0.82 | CHRNA7 (0.40) | HRH3HTR3AALDH1A1MAPTNPC1 | |
| Oxalic Acid SCHEMBL5675074 | 0.81 | HDAC3 (0.48) | HRH3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6542495 | 0.75 | HRH3 (0.42) | HRH3HTR3ACHRNA7 | |
| SCHEMBL6604301 | 0.74 | HTR3A (0.40) | HTR3ASMN1; SMN2CHRNA7 | |
| Bromide SCHEMBL5673167 | 0.74 | HRH3 (0.41) | HRH3HTR3ACHRNA7 | |
| SCHEMBL5358073 | 0.73 | CHRNA7 (0.36) | HTR3AKDM4EALDH1A1HSD17B10RAB9A | |
| SCHEMBL2112299 | 0.70 | CHRNA7 (0.73) | HTR3AKDM4EALDH1A1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289987-B1 | 4-(2-PHENYLTHIAZOL-5-YL)-1,4-DIAZABICYCLO- 3.2.2]NONANE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI SYNTHELABO (FR) | 2004-05-19 | — | — | EP | disclosed |