SCHEMBL6600874

SCHEMBL6600874

O=C(N=S)c1cncnc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 6/20 0.52
TBXA2R P21731 3/20 0.35
TBXAS1 P24557 2/20 0.35
BCAT2 O15382 1/20 0.34
ALDH1A1 P00352 2/20 0.31
APP P05067 1/20 0.31
GAA P10253 1/20 0.31
HCAR3 P49019 1/20 0.31
PLAU P00749 1/20 0.31
VNN1 O95497 1/20 0.31
KDM4E B2RXH2 2/20 0.31
PLOD2 O00469 1/20 0.31
POLB P06746 1/20 0.30
F7 P08709 1/20 0.30
F3 P13726 1/20 0.30
SARM1 Q6SZW1 1/20 0.30
SIRT2 Q8IXJ6 1/20 0.30
SIRT6 Q8N6T7 1/20 0.30
SIRT1 Q96EB6 1/20 0.30
SIRT3 Q9NTG7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27764010 0.74 ALDH1A1 (0.59) HCAR2ALDH1A1APPGAAHCAR3
SCHEMBL30644631 0.73 HCAR2 (0.48) HCAR2TBXA2RTBXAS1BCAT2
SCHEMBL27408226 0.71 HCAR2 (0.65) HCAR2BCAT2ALDH1A1APPGAA
Hydrochloric Acid SCHEMBL27860476 0.69 HCAR2 (0.62) HCAR2BCAT2ALDH1A1APPGAA
SCHEMBL2170133 0.69
SCHEMBL18906052 0.68 HCAR2 (0.54) HCAR2TBXA2RTBXAS1ALDH1A1GAA
SCHEMBL3479005 0.67 HCAR2 (0.42) HCAR2ALDH1A1GAAKDM4EPOLB
SCHEMBL503242 0.67
SCHEMBL2009216 0.67
Hydrochloric Acid SCHEMBL6741706 0.67 HCAR2 (0.94) HCAR2BCAT2ALDH1A1APPGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1235806-A4 NOVEL 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES DONG WHA PHARM IND CO LTD (KR) 2004-02-04 EP disclosed
EP-1235806-A1 NOVEL 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES DONG WHA PHARMACEUTICAL INDUSTRIAL CO. LTD. (KR) 2002-09-04 EP disclosed
WO-2001038308-A1 NOVEL 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES DONG WHA PHARM. IND. CO., LTD (KR) 2001-05-31 WO disclosed