SCHEMBL6600906

SCHEMBL6600906

CN(C(=O)/C=C/C(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)CN[C@H](Cc1ccccc1)c1nnc(OC(N)=O)o1

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 8/20 0.41
ALDH1A1 P00352 3/20 0.33
LMNA P02545 2/20 0.32
PKM P14618 2/20 0.32
HPGD P15428 2/20 0.32
TSHR P16473 2/20 0.32
HTT P42858 2/20 0.32
NPSR1 Q6W5P4 2/20 0.32
HSD17B10 Q99714 2/20 0.32
TP53 P04637 1/20 0.32
MAPT P10636 1/20 0.32
AGTR1 P30556 1/20 0.32
RAB9A P51151 1/20 0.32
MEN1 O00255 1/20 0.32
ALOX15 P16050 1/20 0.32
XBP1 P17861 1/20 0.32
KMT2A Q03164 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
FCER2 P06734 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6600352 0.89 GHSR (0.42) GHSRALDH1A1LMNAPKMHPGD
SCHEMBL7653246 0.74 GHSR (0.46) GHSR
SCHEMBL6600348 0.74 GHSR (0.46) GHSR
SCHEMBL17231305 0.71 GHSR (0.57) GHSRFCER2
SCHEMBL3794280 0.68 GHSR (0.48) GHSR
SCHEMBL3730165 0.68 GHSR (0.48) GHSR
SCHEMBL3794277 0.68 GHSR (0.48) GHSR
SCHEMBL3730166 0.68 GHSR (0.48) GHSR
SCHEMBL3730171 0.68 GHSR (0.48) GHSR
SCHEMBL3730173 0.68 GHSR (0.48) GHSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0805816-B1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2004-07-28 EP claimed