Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 17/20 | 0.49 |
| ▸ | PDE4A | P27815 | 16/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601466 | 0.91 | MAOB (0.56) | PDE4BPDE4APDE4CPDE4DMAOB | |
| SCHEMBL6601661 | 0.91 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4DMAOB | |
| SCHEMBL6603625 | 0.86 | MAOB (0.48) | PDE4BMAOB | |
| SCHEMBL6602629 | 0.86 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DMAOB | |
| SCHEMBL6604768 | 0.85 | MAOB (0.47) | PDE4BMAOB | |
| SCHEMBL6604734 | 0.82 | PDE4B (0.43) | PDE4BPDE4DMAOB | |
| SCHEMBL6601874 | 0.81 | ABCG2 (0.47) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6625815 | 0.81 | MAOB (0.53) | PDE4BPDE4APDE4CPDE4DMAOB | |
| SCHEMBL5203342 | 0.80 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DMAOB | |
| SCHEMBL3324145 | 0.79 | MAOB (0.58) | PDE4BMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922036-B1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 2004-03-24 | — | — | EP | disclosed |
| US-6479494-B1 | THEY INHIBIT SELECTIVELY PHOSPHODIESTERASE IV, WHICH CAUSES AN INCREASE OF THE INTRACELLULAR CAMP LEVEL AS CAMP INHIBITS BONE DECREASING CELLS AND STIMULATES BONE INCREASING CELLS FOR TREATMENT OF OSTEOPOROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-11-12 | — | — | US | disclosed |
| US-6107295-A | Arylalkanoyl pyridazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-22 | — | — | US | disclosed |