Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601466 | 0.92 | MAOB (0.56) | MAOBPDE4BHTTALDH1A1LMNA | |
| SCHEMBL6603625 | 0.87 | MAOB (0.48) | MAOBPDE4BALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6602525 | 0.86 | ALDH1A1 (0.51) | MAOBPDE4BALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6601003 | 0.85 | PDE4B (0.49) | MAOBPDE4B | |
| SCHEMBL6604734 | 0.83 | PDE4B (0.43) | MAOBPDE4BALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6625815 | 0.81 | MAOB (0.53) | MAOBPDE4BHTTALDH1A1LMNA | |
| SCHEMBL6606959 | 0.81 | ABCG2 (0.47) | PDE4BHTTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3324145 | 0.80 | MAOB (0.58) | MAOBPDE4BHTTALDH1A1LMNA | |
| SCHEMBL981491 | 0.78 | MAOB (0.64) | MAOBPDE4BHTTALDH1A1LMNA | |
| SCHEMBL6601399 | 0.78 | MAOB (0.46) | MAOBPDE4BALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922036-B1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 2004-03-24 | — | — | EP | disclosed |
| US-6479494-B1 | THEY INHIBIT SELECTIVELY PHOSPHODIESTERASE IV, WHICH CAUSES AN INCREASE OF THE INTRACELLULAR CAMP LEVEL AS CAMP INHIBITS BONE DECREASING CELLS AND STIMULATES BONE INCREASING CELLS FOR TREATMENT OF OSTEOPOROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-11-12 | — | — | US | disclosed |
| US-6107295-A | Arylalkanoyl pyridazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-22 | — | — | US | disclosed |