Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16136666 | 0.86 | HTR2C (0.37) | HTR2CHTR2AHTR2BCHRNB4CHRNA3 | |
| SCHEMBL5566775 | 0.81 | HTR2C (0.54) | HTR2CHTR2AHTR2BHTR1ASLC6A2 | |
| SCHEMBL20139214 | 0.75 | HTR2C (0.50) | HTR2CHTR2AHTR2B | |
| SCHEMBL30454496 | 0.75 | HTR2C (0.50) | HTR2CHTR2AHTR2B | |
| SCHEMBL20139212 | 0.75 | HTR2C (0.50) | HTR2CHTR2AHTR2B | |
| SCHEMBL7332257 | 0.75 | HTR2C (0.50) | HTR2CHTR2AHTR2B | |
| SCHEMBL4522448 | 0.75 | GID4 (0.39) | HTR2CHTR2AHTR2BPARP1CHRNB4 | |
| Hydrochloric Acid SCHEMBL20141129 | 0.73 | HTR2C (0.51) | HTR2CHTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL20141132 | 0.73 | HTR2C (0.51) | HTR2CHTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL7326909 | 0.73 | HTR2C (0.51) | HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1417190-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | Amgen Inc. (US) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003009850-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC. (US) | 2003-02-06 | — | — | WO | disclosed |