SCHEMBL6601253

SCHEMBL6601253

CCOC(=O)c1noc(C(N)Cc2ccccc2)n1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 2/20 0.57
BMP1 P13497 2/20 0.57
SLC26A6 Q9BXS9 5/20 0.47
SMN1; SMN2 Q16637 4/20 0.42
ALDH1A1 P00352 4/20 0.41
KDM4E B2RXH2 2/20 0.41
NPC1 O15118 1/20 0.41
LMNA P02545 1/20 0.41
GAA P10253 1/20 0.41
MAPT P10636 1/20 0.41
HPGD P15428 1/20 0.41
RAB9A P51151 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
MMP8 P22894 1/20 0.40
ADORA2A P29274 1/20 0.40
ADORA1 P30542 1/20 0.40
MEN1 O00255 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6600914 0.99 MMP2 (0.56) MMP2BMP1SLC26A6SMN1; SMN2ALDH1A1
Hydrochloric Acid SCHEMBL6600911 0.99 MMP2 (0.56) MMP2BMP1SLC26A6SMN1; SMN2ALDH1A1
SCHEMBL6602634 0.83 MMP2 (0.58) MMP2BMP1SLC26A6SMN1; SMN2ALDH1A1
Hydrochloric Acid SCHEMBL8169354 0.82 ALPI (0.42) SMN1; SMN2ALDH1A1KDM4EGAAMAPT
SCHEMBL16145021 0.80 MMP2 (0.55) MMP2BMP1SLC26A6SMN1; SMN2ALDH1A1
SCHEMBL6599890 0.77 TSHR (0.58) MMP2BMP1SMN1; SMN2ALDH1A1LMNA
SCHEMBL13163078 0.77 MMP2 (0.48) MMP2BMP1SLC26A6ALDH1A1KDM4E
Hydrochloric Acid SCHEMBL8906658 0.77 MMP2 (0.44) MMP2BMP1SLC26A6SMN1; SMN2ALDH1A1
SCHEMBL6600399 0.77 MMP2 (0.47) MMP2BMP1SLC26A6
Hydrochloric Acid SCHEMBL6323863 0.76 MMP2 (0.47) MMP2BMP1SLC26A6ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0805816-B1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2004-07-28 EP disclosed
US-6350767-B1 GROWTH HORMONE RELEASE STIMULANT NOVO NORDISK A/S (DK) 2002-02-26 US disclosed
US-6013658-A ANIMAL GROWTH REGULATORS NOVO NORDISK A/S (DK) 2000-01-11 US disclosed
EP-0805816-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1997-11-12 EP disclosed
WO-1996022997-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1996-08-01 WO disclosed