SCHEMBL6600399

SCHEMBL6600399

CCOC(=O)c1noc([C@@H](Cc2ccccc2)NC(=O)[C@H](N)Cc2ccc3ccccc3c2)n1

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 1/20 0.47
BMP1 P13497 1/20 0.47
SRC P12931 4/20 0.44
ZAP70 P43403 3/20 0.44
OPRD1 P41143 1/20 0.42
CTSC P53634 1/20 0.40
TACR1 P25103 1/20 0.39
CTSL P07711 1/20 0.39
CTSB P07858 1/20 0.39
CTSS P25774 1/20 0.39
AGER Q15109 1/20 0.38
PPARD Q03181 1/20 0.38
PPARA Q07869 1/20 0.38
SLC26A6 Q9BXS9 1/20 0.38
MME P08473 1/20 0.38
ACE P12821 1/20 0.38
CPA1 P15085 1/20 0.38
ACE2 Q9BYF1 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6600392 0.99 MMP2 (0.46) MMP2BMP1SRCZAP70OPRD1
SCHEMBL6600672 0.86 ZAP70 (0.46) SRCZAP70OPRD1CTSCMME
Hydrochloric Acid SCHEMBL6600093 0.85 ZAP70 (0.46) SRCZAP70OPRD1CTSCMME
SCHEMBL6602040 0.84 CTSS (0.54) MMP2BMP1SRCZAP70CTSL
SCHEMBL6602038 0.84 CTSS (0.54) MMP2BMP1SRCZAP70CTSL
SCHEMBL6602468 0.84 MMP2 (0.48) MMP2BMP1SRCZAP70TACR1
SCHEMBL6601179 0.83 KLKB1 (0.48) SRCZAP70CTSLCTSS
Hydrochloric Acid SCHEMBL6602463 0.83 MMP2 (0.48) MMP2BMP1SRCZAP70TACR1
Hydrochloric Acid SCHEMBL8168445 0.83 MMP2 (0.48) MMP2BMP1SRCZAP70TACR1
SCHEMBL6605301 0.81 MMP2 (0.43) MMP2BMP1ZAP70TACR1CTSL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0805816-B1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2004-07-28 EP disclosed
US-6350767-B1 GROWTH HORMONE RELEASE STIMULANT NOVO NORDISK A/S (DK) 2002-02-26 US disclosed
US-6013658-A ANIMAL GROWTH REGULATORS NOVO NORDISK A/S (DK) 2000-01-11 US disclosed
EP-0805816-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1997-11-12 EP disclosed
WO-1996022997-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1996-08-01 WO disclosed