Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | APAF1 | O14727 | 4/20 | 0.49 |
| ▸ | CASP3 | P42574 | 4/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 4/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 4/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 4/20 | 0.49 |
| ▸ | CASP6 | P55212 | 3/20 | 0.49 |
| ▸ | CDC25B | P30305 | 6/20 | 0.48 |
| ▸ | SAE1 | Q9UBE0 | 4/20 | 0.48 |
| ▸ | UBA2 | Q9UBT2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | UBE2I | P63279 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | GALK1 | P51570 | 1/20 | 0.48 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20849750 | 0.81 | LOXL2 (0.54) | LOXL2KDM4EGAAAPAF1CASP3 | |
| SCHEMBL30249877 | 0.78 | KDM4E (0.56) | LOXL2KDM4EGAAAPAF1CASP3 | |
| SCHEMBL155511 | 0.78 | KDM4E (0.56) | LOXL2KDM4EGAAAPAF1CASP3 | |
| SCHEMBL155510 | 0.78 | KDM4E (0.56) | LOXL2KDM4EGAAAPAF1CASP3 | |
| SCHEMBL1721134 | 0.77 | KDM4E (0.59) | LOXL2KDM4EGAAAPAF1CASP3 | |
| SCHEMBL28890917 | 0.73 | TNKS2 (0.56) | KDM4EALDH1A1MAPTTNKS2KMT2A | |
| SCHEMBL14948305 | 0.72 | KDM4E (0.53) | LOXL2KDM4EGAAAPAF1CASP3 | |
| SCHEMBL6602571 | 0.72 | CYP2C9 (0.51) | KDM4ECASP3SENP7ALDH1A1MAPT | |
| SCHEMBL1720643 | 0.72 | LOXL2 (0.68) | LOXL2KDM4EGAAAPAF1CASP3 | |
| SCHEMBL23668006 | 0.72 | CDC25B (0.54) | LOXL2KDM4EGAAAPAF1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397350-A1 | ISOQUINOLINONE DERIVATIVES AS PARP INHIBITORS | Kudos Pharmaceuticals Limited (GB) | 2004-03-17 | — | — | EP | disclosed |
| US-6664269-B2 | Adminisetring isoquinolinone compounds for therapy of disease mediated by the enzyme poly(ADP- ribose)polymerase (\"PARP\") | MAYBRIDGE PLC (GB) | 2003-12-16 | — | — | US | disclosed |
| US-20030008896-A1 | Isoquinolinone derivatives | KUDOS PHARMACEUTICALS LIMITED (GB) | 2003-01-09 | — | — | US | disclosed |
| WO-2002090334-A1 | ISOQUINOLINONE DERIVATIVES AS PARP INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2002-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030008896-A1 | Isoquinolinone derivatives | PARP1, PARP2, PARP3 | LOXL2 3607/4885KDM4E 3073/4885GAA 423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.