Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | TNKS | O95271 | 2/20 | 0.46 |
| ▸ | APAF1 | O14727 | 4/20 | 0.44 |
| ▸ | CASP3 | P42574 | 4/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 4/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 4/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.44 |
| ▸ | CASP6 | P55212 | 2/20 | 0.44 |
| ▸ | CDC25B | P30305 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SAE1 | Q9UBE0 | 3/20 | 0.43 |
| ▸ | UBA2 | Q9UBT2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | UBE2I | P63279 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GALK1 | P51570 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30249877 | 0.83 | KDM4E (0.56) | KDM4EGAALOXL2TNKSAPAF1 | |
| SCHEMBL155510 | 0.83 | KDM4E (0.56) | KDM4EGAALOXL2TNKSAPAF1 | |
| SCHEMBL155511 | 0.83 | KDM4E (0.56) | KDM4EGAALOXL2TNKSAPAF1 | |
| SCHEMBL1721134 | 0.83 | KDM4E (0.59) | KDM4EGAALOXL2TNKSAPAF1 | |
| SCHEMBL20849750 | 0.77 | LOXL2 (0.54) | KDM4EGAALOXL2TNKSAPAF1 | |
| SCHEMBL22529424 | 0.76 | ALOX5 (0.60) | KDM4ELOXL2ALDH1A1MAPTALOX5 | |
| SCHEMBL14948301 | 0.74 | CYP1A2 (0.53) | KDM4EGAAALDH1A1HPGDMAPT | |
| SCHEMBL23668005 | 0.74 | CDC25B (0.54) | KDM4EGAALOXL2APAF1CASP3 | |
| SCHEMBL23668006 | 0.74 | CDC25B (0.54) | KDM4EGAALOXL2APAF1CASP3 | |
| SCHEMBL6601327 | 0.72 | LOXL2 (0.51) | KDM4EGAALOXL2TNKSAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815849-B2 | Hetero-bicyclic derivatives as HCV inhibitors | JANSSEN R&D IRELAND (IE) | 2014-08-26 | — | — | US | disclosed |
| US-20130123244-A1 | Hetero-Bicyclic Derivatives as HCV Inhibitors | JANSSEN R&D IRELAND (IL) | 2013-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123244-A1 | Hetero-Bicyclic Derivatives as HCV Inhibitors | HAVCR2, ZC3HAV1, SUB1 | KDM4E 3449/4885GAA 1840/4885LOXL2 4825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.