Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 5/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | PPARA | Q07869 | 3/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603350 | 0.87 | FFAR4 (0.38) | CNR1CNR2PPARDCRHR1SCN9A | |
| SCHEMBL4881385 | 0.82 | CRHR1 (0.40) | CRHR1SCN9APTGDR2 | |
| SCHEMBL4881349 | 0.69 | CRHR1 (0.43) | CRHR1SCN9A | |
| SCHEMBL6204876 | 0.68 | CRHR1 (0.50) | CNR1CNR2CRHR1SCN9APDE2A | |
| SCHEMBL6203432 | 0.67 | CRHR1 (0.53) | CNR1CNR2CRHR1SCN9APDE2A | |
| SCHEMBL12167539 | 0.66 | PTGDR2 (0.49) | PPARDPPARGPPARAPTGDR2 | |
| SCHEMBL6203641 | 0.65 | CRHR1 (0.56) | CNR1CNR2CRHR1SCN9APDE2A | |
| SCHEMBL28423723 | 0.65 | NR5A1 (0.56) | PPARACYP1A1CYP1B1 | |
| SCHEMBL7657330 | 0.65 | MAOB (0.51) | PPARDPPARAPDE2APTGDR2PDK2 | |
| SCHEMBL7660414 | 0.64 | MAOB (0.50) | PPARDPPARAPDE2APDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392302-A1 | 5-SUBSTITUTED-2-ARYLPYRIDINES AS CRF1 MODULATORS | NEUROGEN CORPORATION (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002096421-A1 | 5-SUBSTITUTED-2-ARYLPYRIDINES AS CRF1 MODULATORS | NEUROGEN CORPORATION (US) | 2002-12-05 | — | — | WO | disclosed |