Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.38 |
| ▸ | THRA | P10827 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601464 | 0.87 | CNR1 (0.38) | CRHR1PDK2SCN9ACNR1CNR2 | |
| SCHEMBL4881349 | 0.82 | CRHR1 (0.43) | FFAR4CRHR1CHRM5SCN9ALMNA | |
| SCHEMBL6609362 | 0.78 | CRHR1 (0.46) | FFAR4CRHR1PDK2SCN9ANR1I2 | |
| SCHEMBL6347201 | 0.76 | SCN9A (0.37) | FFAR4CRHR1SCN9ALMNAHTT | |
| SCHEMBL6602770 | 0.72 | CRHR1 (0.54) | FFAR4CRHR1SCN9AFFAR1NR1I2 | |
| SCHEMBL6603304 | 0.71 | CRHR1 (0.46) | FFAR4CRHR1SCN9AFFAR1NR1I2 | |
| SCHEMBL6607143 | 0.71 | CRHR1 (0.54) | FFAR4CRHR1SCN9AFFAR1NR1I2 | |
| SCHEMBL6604201 | 0.70 | CRHR1 (0.49) | FFAR4CRHR1SCN9AFFAR1NR1I2 | |
| SCHEMBL4881385 | 0.69 | CRHR1 (0.40) | CRHR1SCN9ACTSA | |
| SCHEMBL6205729 | 0.69 | CRHR1 (0.55) | FFAR4CRHR1SCN9AFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392302-A1 | 5-SUBSTITUTED-2-ARYLPYRIDINES AS CRF1 MODULATORS | NEUROGEN CORPORATION (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002096421-A1 | 5-SUBSTITUTED-2-ARYLPYRIDINES AS CRF1 MODULATORS | NEUROGEN CORPORATION (US) | 2002-12-05 | — | — | WO | disclosed |