Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.34 |
| ▸ | PDE4A | P27815 | 10/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604510 | 0.87 | LMNA (0.39) | PDE4BPDE4APDE4CPDE4DPSEN1 | |
| SCHEMBL6607333 | 0.81 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL6607331 | 0.81 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL6607329 | 0.81 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL6608366 | 0.80 | PDE4D (0.46) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL6617848 | 0.79 | PDE4A (0.39) | PDE4BPDE4APDE4CPDE4DPSEN1 | |
| SCHEMBL4241620 | 0.78 | PSEN1 (0.35) | PDE4BPDE4APDE4CPDE4DPSEN1 | |
| SCHEMBL11091127 | 0.77 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL4012666 | 0.76 | PDE4B (0.37) | PDE4BPDE4APDE4CPDE4DNPC1 | |
| SCHEMBL6607325 | 0.76 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1110961-B1 | OXYGENIC HETEROCYCLIC COMPOUNDS | KYOWA HAKKO KOGYO KK (JP) | 2004-07-14 | — | — | EP | disclosed |
| US-6376535-B2 | PHOSPHODIESTERASE (PDE) INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2002-04-23 | — | — | US | disclosed |
| US-20010056117-A1 | Oxygen-containing heterocyclic compounds | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2001-12-27 | — | — | US | disclosed |
| EP-1110961-A1 | OXYGENIC HETEROCYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-06-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010056117-A1 | Oxygen-containing heterocyclic compounds | CBR1, CBR3, MT-CO1 | PDE4B 2596/4885PDE4A 2844/4885PDE4C 3154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.