Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 4/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17887361 | 0.75 | AKT1 (0.35) | AKT1CYP3A4TDP1TSHRALDH1A1 | |
| SCHEMBL21082634 | 0.73 | AKT1 (0.34) | AKT1CYP3A4TDP1TSHRALDH1A1 | |
| SCHEMBL1518031 | 0.70 | TDP1 (0.45) | CYP3A4TDP1ALDH1A1ESR1ESR2 | |
| SCHEMBL6156002 | 0.69 | TDP1 (0.50) | CYP3A4TDP1TSHRALDH1A1ESR1 | |
| Ammonia Solution, Strong SCHEMBL4202998 | 0.69 | TDP1 (0.43) | CYP3A4TDP1ESR1ESR2 | |
| Acrylic Acid SCHEMBL11316674 | 0.68 | CYP3A4 (0.57) | AKT1CYP3A4TDP1TSHRALDH1A1 | |
| SCHEMBL31707435 | 0.68 | AKT1 (0.38) | AKT1CYP3A4TDP1TSHRALDH1A1 | |
| SCHEMBL7939706 | 0.67 | CYP3A4 (0.41) | CYP3A4TDP1ALDH1A1ESR1ESR2 | |
| SCHEMBL8721614 | 0.65 | TDP1 (0.45) | CYP3A4TDP1ALDH1A1ESR1ESR2 | |
| SCHEMBL7532752 | 0.65 | CYP3A4 (0.45) | CYP3A4TDP1TSHRALDH1A1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1106612-B1 | Quinoline derivatives useful for inhibiting farnesyl protein transferase | PFIZER PROD INC (US) | 2004-02-11 | — | — | EP | disclosed |
| US-6596735-B1 | Compounds and to the use of said compounds for inhibiting abnormal cell growth in mammals. The compounds of the above formula have activity as farnesyl protein transferase inhibitors. for treatment of cancer andhyperproliferation | PFIZER INC | 2003-07-22 | — | — | US | disclosed |
| EP-1106612-A1 | Quinoline derivatives useful for inhibiting farnesyl protein transferase | Pfizer Products Inc. (US) | 2001-06-13 | — | — | EP | disclosed |