Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 14/20 | 0.42 |
| ▸ | F10 | P00742 | 3/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601603 | 1.00 | GRM2 (0.42) | GRM2F10ITGB3PRSS1PRSS2 | |
| SCHEMBL7639801 | 0.90 | ITGB3 (0.48) | GRM2F10ITGB3PRSS1PRSS2 | |
| SCHEMBL7634297 | 0.90 | ITGB3 (0.48) | GRM2F10ITGB3PRSS1PRSS2 | |
| SCHEMBL7637785 | 0.89 | ITGB3 (0.41) | GRM2F10ITGB3PRSS1PRSS2 | |
| SCHEMBL7639673 | 0.89 | ITGB3 (0.42) | GRM2ITGB3ITGA2B | |
| SCHEMBL7632999 | 0.89 | ITGB3 (0.54) | GRM2F10ITGB3PRSS1PRSS2 | |
| SCHEMBL6601409 | 0.89 | GRM2 (0.48) | GRM2 | |
| SCHEMBL6601383 | 0.88 | GRM2 (0.48) | GRM2F10ITGB3PRSS1PRSS2 | |
| SCHEMBL7640069 | 0.88 | ITGB3 (0.45) | GRM2F10ITGB3PRSS1PRSS2 | |
| SCHEMBL7641745 | 0.87 | ITGB3 (0.40) | GRM2F10ITGB3PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1417190-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | Amgen Inc. (US) | 2004-05-12 | — | — | EP | claimed |
| WO-2003009850-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC. (US) | 2003-02-06 | — | — | WO | claimed |
| EP-0741133-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2004-01-28 | — | — | EP | disclosed |
| EP-0741133-A2 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1996-11-06 | — | — | EP | disclosed |