Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 5/20 | 0.40 |
| ▸ | KCNQ1 | P51787 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | CNR2 | P34972 | 6/20 | 0.36 |
| ▸ | CNR1 | P21554 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602717 | 0.91 | KCNE1 (0.43) | KCNE1KCNQ1ALDH1A1MAPTHTT | |
| SCHEMBL6603010 | 0.89 | CNR2 (0.43) | KCNE1KCNQ1ALDH1A1MAPTHTT | |
| SCHEMBL6604472 | 0.87 | KCNE1 (0.45) | KCNE1KCNQ1ALDH1A1MAPTHTT | |
| SCHEMBL6601925 | 0.87 | KCNE1 (0.44) | KCNE1KCNQ1ALDH1A1MAPTHTT | |
| SCHEMBL6604986 | 0.87 | HPGD (0.45) | KCNE1KCNQ1ALDH1A1MAPTHTT | |
| SCHEMBL6601715 | 0.86 | KCNE1 (0.42) | KCNE1KCNQ1ALDH1A1MAPTHTT | |
| SCHEMBL7900343 | 0.85 | KCNE1 (0.43) | KCNE1KCNQ1ALDH1A1MEN1KMT2A | |
| SCHEMBL6601917 | 0.82 | ALDH1A1 (0.45) | KCNE1KCNQ1ALDH1A1MAPTHTT | |
| SCHEMBL6603289 | 0.81 | KCNE1 (0.44) | KCNE1KCNQ1ALDH1A1MAPTHTT | |
| SCHEMBL6601750 | 0.81 | KCNE1 (0.43) | KCNE1KCNQ1ALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906911-B1 | Sulfonamid-substituted chromane derivatives (K+channel-blocker), process for their preparation, their use as drugsand pharmaceutical compositions containing them | AVENTIS PHARMA GMBH (DE) | 2004-04-28 | — | — | EP | disclosed |
| US-6177449-B1 | CARDIOVASCULAR DISORDERS; ANTIULCER AGENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-01-23 | — | — | US | disclosed |
| EP-0906911-A1 | Sulfonamid-substituted chromane derivatives (K+channel-blocker), process for their preparation, their use as drugsand pharmaceutical compositions containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-04-07 | — | — | EP | disclosed |