Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6441669 | 0.86 | MAPK1 (0.40) | EGFRCACNA1GBCHE | |
| SCHEMBL27971723 | 0.85 | BCHE (0.39) | EGFRBCHE | |
| SCHEMBL6612604 | 0.83 | EGFR (0.52) | EGFRHTTHSD17B10JAK2 | |
| SCHEMBL28775841 | 0.83 | EGFR (0.52) | EGFRHTTHSD17B10JAK2 | |
| SCHEMBL12070134 | 0.83 | EGFR (0.52) | EGFRHTTHSD17B10JAK2 | |
| SCHEMBL27739879 | 0.83 | EGFR (0.52) | EGFRHTTHSD17B10JAK2 | |
| SCHEMBL6601609 | 0.82 | AVPR2 (0.43) | HTTHSD17B10KDM4EBCHE | |
| SCHEMBL6600506 | 0.82 | AVPR2 (0.43) | HTTHSD17B10KDM4EBCHE | |
| SCHEMBL31686030 | 0.78 | CYP1A2 (0.47) | HSD17B10LMNABCHE | |
| SCHEMBL26644922 | 0.78 | CYP1A2 (0.47) | HSD17B10LMNABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877736-B1 | BENZAZEPINE DERIVATIVES WITH VASOPRESSIN AGONISTIC ACTIVITY | OTSUKA PHARMA CO LTD (JP) | 2004-04-21 | — | — | EP | disclosed |
| US-6096736-A | Benzazepine derivatives with vasopressin agonistic activity | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 2000-08-01 | — | — | US | disclosed |
| EP-0877736-A1 | BENZAZEPINE DERIVATIVES WITH VASOPRESSIN AGONISTIC ACTIVITY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-18 | — | — | EP | disclosed |
| WO-1997022591-A1 | BENZAZEPINE DERIVATIVES WITH VASOPRESSIN AGONISTIC ACTIVITY | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1997-06-26 | — | — | WO | disclosed |