Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 16/20 | 0.75 |
| ▸ | HTR1A | P08908 | 15/20 | 0.75 |
| ▸ | DRD4 | P21917 | 4/20 | 0.71 |
| ▸ | DRD3 | P35462 | 4/20 | 0.71 |
| ▸ | DRD2 | P14416 | 6/20 | 0.57 |
| ▸ | HTR2C | P28335 | 2/20 | 0.55 |
| ▸ | HRH1 | P35367 | 2/20 | 0.55 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6600863 | 0.87 | DRD2 (0.76) | HTR1BHTR1ADRD4DRD3DRD2 | |
| SCHEMBL6598730 | 0.83 | HTR1B (0.74) | HTR1BHTR1ADRD4DRD3DRD2 | |
| SCHEMBL6601161 | 0.83 | HTR1B (0.68) | HTR1BHTR1ADRD4DRD3DRD2 | |
| SCHEMBL6598143 | 0.83 | HTR1A (1.00) | HTR1BHTR1ADRD4DRD3DRD2 | |
| SCHEMBL6599312 | 0.82 | HTR1B (0.77) | HTR1BHTR1ADRD4DRD3DRD2 | |
| SCHEMBL6600165 | 0.82 | HTR1A (0.76) | HTR1BHTR1ADRD4DRD3DRD2 | |
| SCHEMBL6598273 | 0.82 | HTR1A (1.00) | HTR1BHTR1ADRD4DRD3DRD2 | |
| SCHEMBL6599135 | 0.81 | HTR1A (0.67) | HTR1BHTR1ADRD4DRD3DRD2 | |
| SCHEMBL6598821 | 0.81 | HTR1B (0.65) | HTR1BHTR1ADRD4DRD3DRD2 | |
| SCHEMBL6601138 | 0.81 | HTR1B (0.65) | HTR1BHTR1ADRD4DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478643-A1 | 5-HETEROARYL SUBSTITUTED INDOLES | H. Lundbeck A/S (DK) | 2004-11-24 | — | — | EP | claimed |
| WO-2003070723-A1 | 5-HETEROARYL SUBSTITUTED INDOLES | H. LUNDBECK A/S (DK) | 2003-08-28 | — | — | WO | claimed |
| EP-1478643-A1 | 5-HETEROARYL SUBSTITUTED INDOLES | H. Lundbeck A/S (DK) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003070723-A1 | 5-HETEROARYL SUBSTITUTED INDOLES | H. LUNDBECK A/S (DK) | 2003-08-28 | — | — | WO | disclosed |