Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 16/20 | 0.61 |
| ▸ | ESR2 | Q92731 | 15/20 | 0.61 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.52 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6600959 | 0.91 | ESR1 (0.61) | ESR1ESR2 | |
| SCHEMBL6601788 | 0.87 | ESR1 (0.69) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL6836592 | 0.85 | ESR1 (0.60) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL6601767 | 0.84 | ESR1 (0.63) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL6601806 | 0.84 | ESR1 (0.54) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL6836553 | 0.80 | ESR1 (0.64) | ESR1ESR2 | |
| SCHEMBL6973749 | 0.80 | ESR1 (0.68) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL6959934 | 0.80 | ESR1 (0.86) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL7663013 | 0.80 | ESR1 (0.86) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL7664893 | 0.80 | ESR1 (0.86) | ESR1ESR2ENPP3ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905132-B1 | Benzothiophenes | LILLY CO ELI (US) | 2004-08-04 | — | — | EP | disclosed |
| US-6060488-A | ANTICARCINOGENIC AGENTS; POSTMENOPAUSAL CANCER OF BREASTS, UTERUS, CERVIX | ELI LILLY AND COMPANY (US) | 2000-05-09 | — | — | US | disclosed |
| EP-0905132-A1 | Benzothiophenes | ELI LILLY AND COMPANY (US) | 1999-03-31 | — | — | EP | disclosed |