Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 16/20 | 0.60 |
| ▸ | ESR2 | Q92731 | 16/20 | 0.60 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.51 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6836603 | 0.90 | ESR1 (0.60) | ESR1ESR2CNR1 | |
| SCHEMBL6601788 | 0.86 | ESR1 (0.69) | ESR1ESR2ENPP3ENPP1CNR1 | |
| SCHEMBL6601884 | 0.85 | ESR1 (0.61) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL6600934 | 0.80 | ESR1 (0.63) | ESR1ESR2ENPP3ENPP1CNR1 | |
| SCHEMBL6836553 | 0.79 | ESR1 (0.64) | ESR1ESR2CNR1 | |
| SCHEMBL6600990 | 0.79 | ESR1 (0.58) | ESR1ESR2ENPP3ENPP1CNR1 | |
| SCHEMBL7452932 | 0.78 | ESR1 (0.76) | ESR1ESR2ENPP3ENPP1CNR1 | |
| SCHEMBL6604899 | 0.78 | ESR1 (0.67) | ESR1ESR2ENPP3ENPP1CNR1 | |
| SCHEMBL6602020 | 0.78 | ESR1 (0.56) | ESR1ESR2ENPP3ENPP1CNR1 | |
| SCHEMBL6603713 | 0.77 | ESR1 (0.61) | ESR1ESR2ENPP3CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756388-B1 | HAVING PIPERIDINYL AND PHENOLIC FUNCTIONALITY; BONE LOSS; BREAST OR PROSTATE CANCER | PFIZER INC. | 2004-06-29 | — | — | US | disclosed |
| EP-0723537-A1 | BENZOTHIOPHENES AND RELATED COMPOUNDS AS ESTROGEN AGONISTS | PFIZER INC. (US) | 1996-07-31 | — | — | EP | disclosed |
| WO-1995010513-A1 | BENZOTHIOPHENES AND RELATED COMPOUNDS AS ESTROGEN AGONISTS | PFIZER INC. (US) | 1995-04-20 | — | — | WO | disclosed |