Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 13/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 9/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 14/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3947626 | 0.80 | CTNNB1 (0.48) | ADRA2ANPY5RMEN1NPC1GAA | |
| SCHEMBL1140966 | 0.77 | P2RX7 (0.42) | P2RX7SMOMEN1NPC1GAA | |
| SCHEMBL6602703 | 0.76 | ADRA2A (0.51) | ADRA2ANPY5RMCHR1 | |
| SCHEMBL3936931 | 0.76 | ADRA2A (0.63) | ADRA2ANPY5RMCHR1 | |
| SCHEMBL3940127 | 0.76 | ADRA2A (0.63) | ADRA2ANPY5RMCHR1 | |
| SCHEMBL3936927 | 0.76 | ADRA2A (0.63) | ADRA2ANPY5RMCHR1 | |
| SCHEMBL3939397 | 0.74 | ADRA2A (0.61) | ADRA2ANPY5RMCHR1 | |
| SCHEMBL1141017 | 0.74 | P2RX7 (0.40) | P2RX7SMOMEN1NPC1GAA | |
| SCHEMBL6614008 | 0.73 | ADRA2A (0.52) | ADRA2ANPY5RKMT2AMCHR1 | |
| SCHEMBL3938288 | 0.72 | ABCG2 (0.47) | ADRA2ANPY5RMEN1NPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432693-A2 | MCH RECEPTOR ANTAGONISTS | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028641-A2 | MCH RECEPTOR ANTAGONISTS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2003-04-10 | — | — | WO | disclosed |