Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.62 |
| ▸ | GSK3B | P49841 | 2/20 | 0.58 |
| ▸ | MMP1 | P03956 | 1/20 | 0.54 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11137241 | 0.95 | PTPN1 (0.57) | PTPN1GSK3BMMP1CES2CES1 | |
| SCHEMBL478183 | 0.85 | PTPN1 (0.66) | PTPN1GSK3BMMP1CES2CES1 | |
| SCHEMBL29987081 | 0.85 | PTPN1 (0.75) | PTPN1GSK3BMMP1CES2CES1 | |
| SCHEMBL9483307 | 0.84 | MAPT (0.48) | PTPN1GSK3BCES1MAPTALDH1A1 | |
| SCHEMBL11138890 | 0.82 | PTPN1 (0.54) | PTPN1GSK3BMMP1CES2CES1 | |
| SCHEMBL3569892 | 0.81 | PTPN1 (0.66) | PTPN1GSK3BMMP1CES2CES1 | |
| SCHEMBL2269889 | 0.80 | MAPT (0.61) | PTPN1GSK3BMMP1CES2CES1 | |
| SCHEMBL11132480 | 0.80 | PTPN1 (0.51) | PTPN1GSK3BMMP1CES2CES1 | |
| SCHEMBL1643579 | 0.79 | PTPN1 (0.73) | PTPN1GSK3BMMP1CES2CES1 | |
| SCHEMBL6604902 | 0.79 | HTR7 (0.56) | PTPN1CES2CES1HDAC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102757-B1 | SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS | GLAXO GROUP LTD (GB) | 2004-04-14 | — | — | EP | disclosed |