Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.43 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28240606 | 0.91 | TSHR (0.47) | TSHRSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6601746 | 0.88 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3KCNH2PARP1 | |
| SCHEMBL30776200 | 0.84 | JAK3 (0.49) | SLC6A2SLC6A4SLC6A3KCNH2PARP1 | |
| SCHEMBL4213803 | 0.84 | JAK3 (0.49) | SLC6A2SLC6A4SLC6A3KCNH2PARP1 | |
| SCHEMBL1663055 | 0.84 | JAK3 (0.49) | SLC6A2SLC6A4SLC6A3KCNH2PARP1 | |
| SCHEMBL2857686 | 0.82 | TSHR (0.55) | TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1822134 | 0.81 | HTR3A (0.49) | SLC6A2SLC6A4SLC6A3KCNH2HTR3A | |
| SCHEMBL9635880 | 0.81 | CYP3A4 (0.48) | SLC6A2SLC6A4SLC6A3KCNH2PARP1 | |
| SCHEMBL22608987 | 0.80 | CHRNB2 (0.47) | HTR3A | |
| SCHEMBL10784543 | 0.79 | JAK3 (0.45) | SLC6A2SLC6A4SLC6A3KCNH2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877736-B1 | BENZAZEPINE DERIVATIVES WITH VASOPRESSIN AGONISTIC ACTIVITY | OTSUKA PHARMA CO LTD (JP) | 2004-04-21 | — | — | EP | disclosed |
| US-6096736-A | Benzazepine derivatives with vasopressin agonistic activity | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 2000-08-01 | — | — | US | disclosed |
| EP-0877736-A1 | BENZAZEPINE DERIVATIVES WITH VASOPRESSIN AGONISTIC ACTIVITY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-18 | — | — | EP | disclosed |
| WO-1997022591-A1 | BENZAZEPINE DERIVATIVES WITH VASOPRESSIN AGONISTIC ACTIVITY | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1997-06-26 | — | — | WO | disclosed |