Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chlorzoxazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CETP | P11597 | 2/20 | 0.48 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11443651 | 0.84 | MEN1 (0.62) | RAB9AMAPTMEN1KMT2AALDH1A1 | |
| Chlorzoxazone SCHEMBL35177 | 0.81 | KDM4E (0.70) | KDM4ERAB9AMAPTMEN1KMT2A | |
| Chlorzoxazone SCHEMBL27696905 | 0.78 | KDM4E (0.66) | KDM4ERAB9AMAPTMEN1KMT2A | |
| SCHEMBL31532248 | 0.75 | FBP1 (0.57) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| Acetaminophen SCHEMBL2518811 | 0.74 | NPC1 (0.68) | KDM4ERAB9AMAPTMEN1KMT2A | |
| SCHEMBL2244450 | 0.74 | RAB9A (0.60) | RAB9AMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3856571 | 0.73 | RAB9A (0.56) | RAB9AMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3758562 | 0.73 | RAB9A (0.56) | RAB9AMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3194691 | 0.73 | RAB9A (0.76) | KDM4ERAB9AMAPTMEN1KMT2A | |
| Chlorzoxazone SCHEMBL8681418 | 0.73 | KDM4E (0.63) | KDM4ERAB9AMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1646519-A | N-oxides of N-phenyl-2-pyrimidine-amine derivatives | NOVARTIS AG (CH) | 2005-07-27 | — | — | CN | disclosed |
| EP-1470120-A1 | N-OXYDE OF N-PHENYL-2-PYRIMIDINE-AMINE DERIVATIVES | Novartis AG (CH) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003062220-A1 | N-OXYDE OF N-PHENYL-2-PYRIMIDINE-AMINE DERIVATIVES | NOVARTIS AG (CH) | 2003-07-31 | — | — | WO | disclosed |