SCHEMBL6602368

SCHEMBL6602368

Cc1sc(-c2ccc(F)cc2)nc1CCO

nearest known ligand 0.59

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
DCK P27707 2/20 0.53
PPARG P37231 1/20 0.46
PPARA Q07869 1/20 0.46
TRPM8 Q7Z2W7 1/20 0.44
APP P05067 2/20 0.43
TP53 P04637 2/20 0.42
MAPT P10636 2/20 0.41
ALOX5 P09917 1/20 0.41
LMNA P02545 1/20 0.41
SULT1A1 P50225 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL820915 0.87 PPARA (0.49) DCKPPARGPPARATRPM8ALOX5
SCHEMBL3372455 0.84 APEX1 (0.47) PPARGPPARATRPM8MAPT
SCHEMBL4889434 0.84 RARA (0.51) PPARGPPARAMAPTALOX5
SCHEMBL1436076 0.84 RARA (0.50) PPARGPPARAMAPTALOX5
SCHEMBL968444 0.84 NPC1 (0.49) PPARGPPARAMAPT
SCHEMBL3540243 0.84 DCK (0.39) DCKPPARGPPARAMAPTLMNA
SCHEMBL27607268 0.83 DCK (0.40) DCKPPARAMAPTLMNA
SCHEMBL7922445 0.83 MEN1 (0.45) PPARGPPARAMAPT
SCHEMBL6602682 0.82 DCK (0.55) DCKTRPM8TP53MAPTLMNA
SCHEMBL3368282 0.82 MAPT (0.46) PPARATP53MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1102757-B1 SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS GLAXO GROUP LTD (GB) 2004-04-14 EP disclosed
WO-2004011446-A1 INDANE, DIHYDROBENZOFURAN, AND TETRAHYDRONAPHTHALENE CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ANTIDIABETICS BAYER PHARMACEUTICALS CORPORATION (US) 2004-02-05 WO disclosed
US-6498174-B1 AGONISTS TO PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; MODULATING BLOOD GLUCOSE AND LIPID LEVELS; REDUCING DYSLIPIDEMIA AND HYPERINSULINEMIA ASSOCIATED WITH IMPAIRED GLUCOSE TOLERANCE OR METABOLIC SYNDROME SMITHKLINE BEECHAM CORPORATION 2002-12-24 US disclosed
EP-1102757-A1 SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS GLAXO GROUP LIMITED (GB) 2001-05-30 EP disclosed
WO-2000008002-A1 SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS hPPAR GAMMA AND hPPAR ALPHA ACTIVATORS GLAXO GROUP LIMITED (GB) 2000-02-17 WO disclosed