Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 13/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6605929 | 0.93 | ALDH1A1 (0.48) | ALDH1A1POLBPGRGAAMAOB | |
| SCHEMBL144189 | 0.89 | ALDH1A1 (0.45) | ALDH1A1POLBPGRGAAMAOB | |
| SCHEMBL6601093 | 0.89 | ALDH1A1 (0.45) | ALDH1A1POLBPGRGAASMN1; SMN2 | |
| SCHEMBL6601921 | 0.89 | MAOB (0.57) | ALDH1A1POLBPGRGAAMAOB | |
| SCHEMBL6600023 | 0.88 | ALDH1A1 (0.46) | ALDH1A1POLBPGRGAAMAOB | |
| SCHEMBL6602412 | 0.87 | ALDH1A1 (0.52) | ALDH1A1POLBPGRGAAMAOB | |
| SCHEMBL6602252 | 0.87 | ALDH1A1 (0.47) | ALDH1A1POLBPGRGAASMN1; SMN2 | |
| SCHEMBL6603127 | 0.86 | MAPT (0.47) | ALDH1A1POLBGAASMN1; SMN2LMNA | |
| SCHEMBL6603562 | 0.86 | ALDH1A1 (0.42) | ALDH1A1POLBPGRGAASMN1; SMN2 | |
| SCHEMBL6605418 | 0.86 | ALDH1A1 (0.42) | ALDH1A1POLBPGRGAAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922036-B1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 2004-03-24 | — | — | EP | disclosed |
| US-6479494-B1 | THEY INHIBIT SELECTIVELY PHOSPHODIESTERASE IV, WHICH CAUSES AN INCREASE OF THE INTRACELLULAR CAMP LEVEL AS CAMP INHIBITS BONE DECREASING CELLS AND STIMULATES BONE INCREASING CELLS FOR TREATMENT OF OSTEOPOROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-11-12 | — | — | US | disclosed |
| US-6107295-A | Arylalkanoyl pyridazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-22 | — | — | US | disclosed |