Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 7/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6600023 | 0.92 | ALDH1A1 (0.46) | ALDH1A1POLBSMN1; SMN2PGRMAPT | |
| SCHEMBL6603519 | 0.91 | MEN1 (0.45) | ALDH1A1POLBGRM4SMN1; SMN2NPC1 | |
| SCHEMBL6601572 | 0.90 | NPC1 (0.56) | ALDH1A1POLBGRM4AURKBSMN1; SMN2 | |
| SCHEMBL6603562 | 0.90 | ALDH1A1 (0.42) | ALDH1A1POLBGRM4SMN1; SMN2PGR | |
| SCHEMBL6601093 | 0.88 | ALDH1A1 (0.45) | ALDH1A1POLBSMN1; SMN2KDM4EPGR | |
| SCHEMBL6606987 | 0.88 | PGR (0.43) | ALDH1A1POLBSMN1; SMN2PGRMAPT | |
| SCHEMBL6605929 | 0.87 | ALDH1A1 (0.48) | ALDH1A1POLBSMN1; SMN2PGRMAPT | |
| SCHEMBL6602474 | 0.87 | ALDH1A1 (0.48) | ALDH1A1POLBSMN1; SMN2PGRMAPT | |
| SCHEMBL146153 | 0.87 | ABCG2 (0.45) | ALDH1A1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL6600779 | 0.86 | NPC1 (0.49) | ALDH1A1POLBGRM4AURKBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922036-B1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 2004-03-24 | — | — | EP | disclosed |
| US-6479494-B1 | THEY INHIBIT SELECTIVELY PHOSPHODIESTERASE IV, WHICH CAUSES AN INCREASE OF THE INTRACELLULAR CAMP LEVEL AS CAMP INHIBITS BONE DECREASING CELLS AND STIMULATES BONE INCREASING CELLS FOR TREATMENT OF OSTEOPOROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-11-12 | — | — | US | disclosed |
| US-6107295-A | Arylalkanoyl pyridazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-22 | — | — | US | disclosed |