Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601908 | 1.00 | L3MBTL1 (0.45) | L3MBTL1DDB1CRBNGPBAR1BRD4 | |
| SCHEMBL16148460 | 0.79 | L3MBTL1 (0.45) | L3MBTL1NPSR1CTSLHDAC3HDAC1 | |
| SCHEMBL16148462 | 0.79 | L3MBTL1 (0.45) | L3MBTL1NPSR1CTSLHDAC3HDAC1 | |
| SCHEMBL6628392 | 0.77 | DDB1 (0.42) | DDB1CRBNBRD4CREBBP | |
| SCHEMBL6601732 | 0.77 | DDB1 (0.42) | DDB1CRBNBRD4CREBBP | |
| SCHEMBL5435739 | 0.77 | L3MBTL1 (0.52) | L3MBTL1NPSR1CTSLHDAC3HDAC1 | |
| SCHEMBL4403092 | 0.72 | L3MBTL1 (0.58) | L3MBTL1NPSR1HDAC3HDAC1HDAC2 | |
| SCHEMBL7619127 | 0.71 | L3MBTL1 (0.56) | L3MBTL1NPSR1CTSLHDAC3HDAC1 | |
| SCHEMBL28304424 | 0.71 | L3MBTL1 (0.40) | L3MBTL1NPSR1CTSL | |
| SCHEMBL9956054 | 0.70 | L3MBTL1 (0.43) | L3MBTL1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444202-A1 | NOVEL METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003040098-A1 | NOVEL METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2003-05-15 | — | — | WO | disclosed |