Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 6/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 6/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6628392 | 1.00 | DDB1 (0.42) | DDB1CRBNBRD4CREBBPGAA | |
| SCHEMBL6602502 | 0.77 | L3MBTL1 (0.45) | DDB1CRBNBRD4CREBBP | |
| SCHEMBL6601908 | 0.77 | L3MBTL1 (0.45) | DDB1CRBNBRD4CREBBP | |
| SCHEMBL25036123 | 0.70 | DDB1 (0.48) | DDB1CRBN | |
| SCHEMBL27972081 | 0.67 | CRBN (0.39) | DDB1CRBNMAP3K14 | |
| SCHEMBL29967266 | 0.67 | MAPK1 (0.42) | DDB1CRBNGAANFKB1NFKB2 | |
| SCHEMBL5354362 | 0.65 | DDB1 (0.36) | DDB1CRBNBRD4CREBBPNFKB1 | |
| SCHEMBL1773976 | 0.65 | CRBN (0.40) | DDB1CRBNBRD4CREBBPGAA | |
| SCHEMBL8736478 | 0.65 | MAP3K14 (0.44) | DDB1CRBNGAAMAP3K14TSHR | |
| SCHEMBL14277693 | 0.64 | GAA (0.59) | DDB1CRBNBRD4CREBBPGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444202-A1 | NOVEL METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003040098-A1 | NOVEL METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2003-05-15 | — | — | WO | disclosed |