Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.52 |
| ▸ | CTSV | O60911 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NAAA | Q02083 | 2/20 | 0.31 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602874 | 1.00 | CTSK (0.52) | CTSKCTSVCTSSKCNK3MAPK1 | |
| SCHEMBL6403139 | 0.87 | CTSK (0.40) | CTSKCTSVCTSSKCNK3MAPK1 | |
| SCHEMBL6406284 | 0.87 | CTSK (0.40) | CTSKCTSVCTSSKCNK3MAPK1 | |
| SCHEMBL6403133 | 0.78 | CTSK (0.43) | CTSKCTSVCTSSKCNK3MAPK1 | |
| SCHEMBL6406277 | 0.78 | CTSK (0.43) | CTSKCTSVCTSSKCNK3MAPK1 | |
| SCHEMBL6601981 | 0.76 | PKM (0.56) | CTSKMAPK1LMNAMAPT | |
| SCHEMBL6403144 | 0.72 | CTSK (0.42) | CTSKCTSVCTSSKCNK3MAPK1 | |
| SCHEMBL15577656 | 0.71 | CTSK (0.41) | CTSKKCNK3MAPK1POLBMAPT | |
| SCHEMBL4811438 | 0.70 | CTSK (0.50) | CTSKCTSVCTSSPOLB | |
| SCHEMBL6402731 | 0.70 | HTT (0.50) | CTSKPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411933-A1 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN K INHIBITORS | SmithKline Beecham Corporation (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003013518-A1 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN K INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-02-20 | — | — | WO | disclosed |