SCHEMBL6602923

SCHEMBL6602923

CCCN(CCC)CCOc1cc(NC(=O)c2ccc(-c3ccccn3)cc2)ccc1OC

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 12/20 0.64
HTR2C P28335 2/20 0.55
KDM4E B2RXH2 2/20 0.50
NPC1 O15118 1/20 0.50
RAB9A P51151 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
TRPV1 Q8NER1 1/20 0.50
MEN1 O00255 1/20 0.49
ALDH1A1 P00352 1/20 0.49
TP53 P04637 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
MAPT P10636 1/20 0.49
HPGD P15428 1/20 0.49
ALOX15 P16050 1/20 0.49
HTR1D P28221 1/20 0.49
HTR1B P28222 1/20 0.49
HTR2A P28223 1/20 0.49
MAPK1 P28482 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6921907 0.89 MCHR1 (0.80) MCHR1HTR2C
SCHEMBL6605998 0.87 MCHR1 (0.64) MCHR1HTR2CTRPV1
SCHEMBL6602916 0.87 MCHR1 (0.73) MCHR1HTR2C
SCHEMBL6602569 0.87 MCHR1 (0.65) MCHR1HTR2CKDM4EMEN1ALDH1A1
SCHEMBL6898088 0.87 MCHR1 (0.67) MCHR1HTR2CNPC1RAB9ASMN1; SMN2
SCHEMBL6896989 0.85 MCHR1 (0.67) MCHR1HTR2CNPC1RAB9ASMN1; SMN2
SCHEMBL6605156 0.85 MCHR1 (0.65) MCHR1HTR2CMAPT
SCHEMBL6899005 0.83 MCHR1 (0.63) MCHR1HTR2CNPC1RAB9ASMN1; SMN2
SCHEMBL6895401 0.83 MCHR1 (0.70) MCHR1HTR2CNPC1RAB9ASMN1; SMN2
SCHEMBL6899096 0.83 MCHR1 (0.70) MCHR1HTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1102535-A4 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2004-09-29 EP claimed
EP-1102535-A2 COMPOUNDS AND METHODS SmithKline Beecham Corporation (US) 2001-05-30 EP claimed
WO-2000006085-A2 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2000-02-10 WO claimed
EP-1102535-A4 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2004-09-29 EP disclosed
EP-1102535-A2 COMPOUNDS AND METHODS SmithKline Beecham Corporation (US) 2001-05-30 EP disclosed
WO-2000006085-A2 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2000-02-10 WO disclosed