SCHEMBL6602569

SCHEMBL6602569

CCCN(CCC)CCOc1cc(NC(=O)c2ccc(-c3ccncc3)cc2)ccc1OC

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 9/20 0.65
HTR2C P28335 1/20 0.56
HTR1D P28221 5/20 0.55
HTR1B P28222 5/20 0.55
NAMPT P43490 1/20 0.52
HTR1A P08908 1/20 0.52
KDM4E B2RXH2 1/20 0.51
MEN1 O00255 1/20 0.51
ALDH1A1 P00352 1/20 0.51
TP53 P04637 1/20 0.51
CYP1A2 P05177 1/20 0.51
CYP3A4 P08684 1/20 0.51
CYP2D6 P10635 1/20 0.51
MAPT P10636 1/20 0.51
HPGD P15428 1/20 0.51
ALOX15 P16050 1/20 0.51
HTR2A P28223 1/20 0.51
MAPK1 P28482 1/20 0.51
KMT2A Q03164 1/20 0.51
HSD17B10 Q99714 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6921907 0.90 MCHR1 (0.80) MCHR1HTR2C
SCHEMBL6605156 0.90 MCHR1 (0.65) MCHR1HTR2CMAPT
SCHEMBL6602923 0.87 MCHR1 (0.64) MCHR1HTR2CHTR1DHTR1BKDM4E
SCHEMBL6602562 0.86 MCHR1 (0.75) MCHR1HTR2CHTR1DHTR1B
SCHEMBL6605102 0.86 MCHR1 (0.58) MCHR1HTR2CHTR1DHTR1BNAMPT
SCHEMBL6604269 0.85 MCHR1 (0.61) MCHR1HTR2CKDM4EMEN1ALDH1A1
SCHEMBL6606159 0.84 ALDH1A1 (0.56) MCHR1KDM4EALDH1A1MAPTMAPK1
SCHEMBL6898088 0.84 MCHR1 (0.67) MCHR1HTR2CALDH1A1TP53
SCHEMBL6896989 0.84 MCHR1 (0.67) MCHR1HTR2CMEN1ALDH1A1TP53
SCHEMBL6894749 0.83 MCHR1 (0.64) MCHR1HTR2CALDH1A1TP53MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1102535-A4 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2004-09-29 EP disclosed
EP-1102535-A2 COMPOUNDS AND METHODS SmithKline Beecham Corporation (US) 2001-05-30 EP disclosed
WO-2000006085-A2 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2000-02-10 WO disclosed