Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.38 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.38 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7222277 | 0.82 | ALDH1A1 (0.47) | ALDH1A1TSHRMEN1KMT2ATDP1 | |
| SCHEMBL25376149 | 0.81 | ALDH1A1 (0.53) | ALDH1A1TSHRMEN1KMT2ATDP1 | |
| SCHEMBL2260806 | 0.78 | ALDH1A1 (0.50) | ALDH1A1TSHRMEN1KMT2ATDP1 | |
| SCHEMBL30162663 | 0.78 | ALDH1A1 (0.50) | ALDH1A1TSHRMEN1KMT2ATDP1 | |
| SCHEMBL17263930 | 0.78 | TSHR (0.64) | ALDH1A1TSHRMEN1KMT2ATDP1 | |
| SCHEMBL26373121 | 0.76 | ALDH1A1 (0.51) | ALDH1A1TSHRMEN1KMT2ATDP1 | |
| SCHEMBL25377549 | 0.75 | PDE3B (0.48) | ALDH1A1KMT2ALMNAHTTPOLB | |
| SCHEMBL25373700 | 0.75 | MAPT (0.55) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL25376257 | 0.75 | ALDH1A1 (0.47) | ALDH1A1TSHRMEN1KMT2ATDP1 | |
| SCHEMBL30402540 | 0.75 | ALDH1A1 (0.47) | ALDH1A1TSHRMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109809-B1 | PYRROLOQUINOLINES FOR TREATMENT OF OBESITY | CEREBRUS PHARM LTD (GB) | 2004-11-17 | — | — | EP | disclosed |
| US-6365598-B1 | FOR THERAPY AND PROPHYLAXIS OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM; DAMAGE TO THE CENTRAL NERVOUS SYSTEM; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS; DIABETES INSIPIDUS; AND SLEEP APNEA | VERNALIS RESEARCH LIMITED (GB) | 2002-04-02 | — | — | US | disclosed |
| EP-1109809-A1 | PYRROLOQUINOLINES FOR TREATMENT OF OBESITY | Cerebrus Pharmaceuticals Limited (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012502-A1 | PYRROLOQUINOLINES FOR TREATMENT OF OBESITY | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |