Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | TOP2A | P11388 | 1/20 | 0.30 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6598651 | 0.96 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL6599108 | 0.85 | MAPK1 (0.39) | SLC6A2SLC6A4SLC6A3MAPK1KCNH2 | |
| SCHEMBL6599636 | 0.84 | F10 (0.36) | — | |
| SCHEMBL6598734 | 0.80 | F10 (0.36) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6599020 | 0.80 | F10 (0.36) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6603094 | 0.80 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3MAPK1KCNH2 | |
| SCHEMBL6598690 | 0.78 | UTS2R (0.38) | SLC6A2SLC6A4KCNH2CYP2D6 | |
| SCHEMBL6598656 | 0.78 | UTS2R (0.38) | SLC6A2SLC6A4KCNH2CYP2D6 | |
| SCHEMBL6598653 | 0.77 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3MAPK1KCNH2 | |
| SCHEMBL6739732 | 0.76 | UTS2R (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379503-A1 | PYRROLIDINE SULFONAMIDES | SmithKline Beecham Corporation (US) | 2004-01-14 | — | — | EP | claimed |
| WO-2002079155-A1 | PYRROLIDINE SULFONAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | claimed |
| EP-1379503-A1 | PYRROLIDINE SULFONAMIDES | SmithKline Beecham Corporation (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002079155-A1 | PYRROLIDINE SULFONAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | disclosed |